A short stereoselective synthesis of (+)-(6R,2′S)-cryptocaryalactone via ring- closing metathesis

• Palakodety Radha Krishna,
• Krishnarao Lopinti and
• K. L. N. Reddy

Beilstein J. Org. Chem. 2009, 5, No. 14, doi:10.3762/bjoc.5.14

• : Carreira asymmetric alkynylation; Cryptocarya bourdilloni GAMB (Lauraceae); ring-closing metathesis; Sharpless asymmetric epoxidation; Introduction Natural products play an important role in the development of drugs and mankind has always taken advantage of nature as pharmacy: approximately 40% of the

• ], (+)-obolactone (4) [29] and (+)-cryptofoline (5) [30] (Figure 1) are some of the naturally occurring styryl lactones. (+)-(6R,2′S)-Cryptocaryalactone (1) first featured in the phytochemical literature when its isolation from Cryptocarya bourdilloni GAMB (Lauraceae) was reported in 1972 by Govindachari [31][32